Thermo Fisher Scientific Neuritin Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human NRN1(Accession Q9NPD7), corresponding to amino acid residues A28-T78. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Neuritin,uniProtId:Q9NPD7-1,ncbiNodeId:9606,antigenRange:28-78,antigenLength:142,antigenImageFileName:PA5-100209_Neuritin_Q9NPD7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-100209_Neuritin_Q9NPD7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2815739

Product Specific Information

Antibody detects endogenous levels of total NRN1.

Target Information

Neuritin belongs to the neuritin family and is expressed in postmitotic-differentiating neurons of the developmental nervous system as well as neuronal structures associated with plasticity in adults. Its expression can be induced by neural activity and neurotrophins. The protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins and promotes neurite outgrowth and arborization, indicating its role in promoting neuritogenesis. Overexpression of the protein may be associated with astrocytoma progression. Alternative splicing leads to multiple transcript variants. NRN1 is associated with Severe Congenital Neutropenia 8 and Spinal Muscular Atrophy, Type III.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.