Thermo Fisher Scientific MRPL12 Polyclonal Antibody

Applications

• Western Blot (WB): 1 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence: KKTLKIQDVG LVPMGGVMSG AVPAAAAQEA VEEDIPIAKE RTHFTVRLTE
• Sequence homology: Dog: 77%; Human: 100%

Target Information

MRPL12 (mitochondrial ribosomal protein L12), also referred to as 5c5-2, L12mt, MRPL7 or RPML12, is a mammalian mitochondrial ribosomal protein involved in protein synthesis within the mitochondrion.
MRPL12 is enhanced in growth-stimulated cells due to transcriptional activation, suggesting a role as a translational regulator of mitochondrial mRNAs.
Impairment of MRPL12 leads to reduced cell growth rate, decreased mitochondrial ATP production, and loss of oxidative phosphorylation.
It is cleaved during mitochondrial translocation, exists as dimers binding the large ribosomal subunit, and is 198 amino acids in length.
Belongs to the ribosomal protein L12P family and is highly expressed in the colon.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.