Thermo Fisher Scientific HTR2A Polyclonal Antibody
Rabbit polyclonal antibody against human HTR2A protein. Recognizes serotonin receptor subtype 2A involved in neurotransmission and cardiovascular functions. Supplied as liquid, unconjugated, 0.2 mg/mL concentration. Suitable for research use only.
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- PA553111
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Thermo Fisher Scientific HTR2A Polyclonal Antibody
Product Specifications
| 항목 | 내용 |
|---|---|
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HTR2A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642584 |
Product Specific Information
Immunogen sequence:
TIKSLQKEAT LCVSDLGTRA KLASFSFLPQ SSLSSEKLFQ RSIHREPGSY TGRRTMQSIS NEQ
Highest antigen sequence identity to the following orthologs:
- Mouse: 95%
- Rat: 97%
Target Information
Serotonin plays a major role in cardiovascular function and gastrointestinal motility. It mediates its effects through several G protein-coupled receptors known as 5-HT or SR receptors.
SR-2 receptors include subtypes SR-2A, SR-2B, and SR-2C, which activate phospholipase C and release intracellular calcium in response to serotonin.
- SR-2A: Involved in tracheal smooth muscle contraction, bronchoconstriction, aldosterone production, and linked to psychiatric disorders such as depression and schizophrenia.
- SR-2B: Expressed in cardiovascular tissues, gut, and brain; important in cardiac pathology.
- SR-2C: Mediates effects of atypical antipsychotic drugs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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