Thermo Fisher Scientific CHFR Polyclonal Antibody
CHFR 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC에 적합합니다. 인간 시료 반응성이 있으며, 고순도 Affinity Chromatography 정제 제품입니다. 항암 및 세포주기 조절 연구에 활용됩니다.
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- PA542327
- 판매단위
- pk
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Thermo Fisher Scientific CHFR Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human CHFR (aa 36–85) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2606127 |
Product Specific Information
- Peptide sequence: REWTIGRRRG CDLSFPSNKL VSGDHCRIVV DEKSGQVTLE DTSTSGTVIN
- Sequence homology:
Cow: 93%
Dog: 93%
Guinea Pig: 100%
Horse: 93%
Human: 100%
Mouse: 100%
Rabbit: 100%
Rat: 100%
Zebrafish: 86%
Target Information
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosomes move apart along the periphery of the nucleus. Involved in signaling mitotic stress caused by microtubule poisons by mediating Lys-48–linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes ubiquitination and degradation of AURKA and PLK1. Acts as a tumor suppressor, possibly by mediating polyubiquitination of HDAC1. May also promote Lys-63–linked polyubiquitin chain formation with the UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates polyubiquitinated at Lys-63 are generally involved in stress signaling rather than degradation.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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