Thermo Fisher Scientific CHFR Polyclonal Antibody

Thermo Fisher Scientific CHFR Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Peptide sequence: REWTIGRRRG CDLSFPSNKL VSGDHCRIVV DEKSGQVTLE DTSTSGTVIN
• Sequence homology:
  Cow: 93%
  Dog: 93%
  Guinea Pig: 100%
  Horse: 93%
  Human: 100%
  Mouse: 100%
  Rabbit: 100%
  Rat: 100%
  Zebrafish: 86%

Target Information

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosomes move apart along the periphery of the nucleus. Involved in signaling mitotic stress caused by microtubule poisons by mediating Lys-48–linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes ubiquitination and degradation of AURKA and PLK1. Acts as a tumor suppressor, possibly by mediating polyubiquitination of HDAC1. May also promote Lys-63–linked polyubiquitin chain formation with the UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates polyubiquitinated at Lys-63 are generally involved in stress signaling rather than degradation.

Usage Notice

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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