Thermo Fisher Scientific PAPD5 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.3-1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide with sequence C-HALPAEQRDFLP. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PAPD5,uniProtId:Q8NDF8-1,ncbiNodeId:9606,antigenRange:12-23,antigenLength:572,antigenImageFileName:PA5-142725_PAPD5_Q8NDF8-1_Goat.svg,antigenImageFileNamePDP:PA5-142725_PAPD5_Q8NDF8-1_Goat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2933371

Product Specific Information

Additional Information: This antibody is expected to recognize both reported isoforms (NP_001035374.2; NP_001035375.2).

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.

Target Information

Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3poly(A) tail creating a heterogeneous 3 poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:21788334, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesnt need a cofactor for polyadenylation activity (in vitro) (PubMed:21788334, PubMed:21855801). Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 (PubMed:28383716). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (PubMed:18172165). Mediates 3 adenylation of the microRNA MIR21 followed by its 3-to-5 trimming by the exoribonuclease PARN leading to degradation (PubMed:25049417). Mediates 3adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3-to-5` trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation (PubMed:22442037). [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.