Thermo Fisher Scientific Human UNC93B1 Synthetic Peptide
인간 UNC93B1 단백질의 N-말단 19개 아미노산 서열을 기반으로 한 합성 펩타이드입니다. 항체 차단 실험에 사용 가능하며, 인간 단백질 반응성 확인용으로 적합합니다. 액상 형태로 제공되며 PBS 버퍼에 안정화되어 연구용으로 사용됩니다.
- 카탈로그번호
- PEP0630
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 19 amino acids near the amino terminus of human Unc93b.
PEP-0630 can be used as a blocking peptide with polyclonal antibody PA5-20510.
Target Information
The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling.
Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9; the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction.
Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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