Thermo Fisher Scientific SLC6A8 Polyclonal Antibody
Thermo Fisher의 SLC6A8 폴리클로날 항체는 인간 SLC6A8 단백질의 N-말단 펩타이드(aa 200-249)에 특이적으로 결합합니다. Western blot 및 IHC(P)에서 검증되었으며, 단백질 A로 정제된 액상 항체로 다양한 조직의 크레아틴 운반체 연구에 적합합니다.
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Thermo Fisher Scientific SLC6A8 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 4–8 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human SLC6A8 (aa 200–249) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2608716 |
Product Specific Information
- Peptide sequence: CDQLADRRSP VIEFWENKVL RLSGGLEVPG ALNWEVTLCL LACWVLVYFC
- Sequence homology:
Cow: 100% / Dog: 100% / Guinea Pig: 100% / Horse: 100% / Human: 100% / Mouse: 100% / Rabbit: 93% / Rat: 100%
Target Information
SLC6A8 (solute carrier family 6 member 8), also known as CT1 (creatine transporter 1), CRT or CRTR, is a 635 amino acid multi-pass plasma membrane protein belonging to the sodium/neurotransmitter (SNF) family.
It is expressed in various tissues including kidney, skeletal muscle, heart, brain, prostate, testis, and colon. SLC6A8 functions to transport creatine into and out of cells, particularly in brain and muscle tissue.
Creatine is essential for supplying energy required for proper muscle and nerve function.
Defects in the SLC6A8 gene lead to cerebral creatine deficiency and cause X-linked creatine deficiency syndrome, characterized by facial anomalies, seizures, and mental retardation.
Multiple isoforms of SLC6A8 exist due to alternative splicing events.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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