Thermo Fisher Scientific MASP2 Polyclonal Antibody
MASP2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. 인간 시료에 반응하며, 고순도 Affinity Chromatography로 정제. 연구용으로 면역 반응 및 보체 경로 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human MASP2 (aa 35–84) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2610544 |
Product Specific Information
- Peptide sequence: FPGEYANDQE RRWTLTAPPG YRLRLYFTHF DLELSHLCEY DFVKLSSGAK
- Sequence homology:
- Cow: 100%
- Dog: 100%
- Guinea Pig: 100%
- Horse: 100%
- Human: 100%
- Mouse: 100%
- Rat: 100%
- Zebrafish: 77%
Target Information
Mannose (or mannan)-binding lectin (MBL), also known as serum mannose-binding protein (MBP), initiates the lectin branch of the innate immune response by binding to the surface of pathogenic microorganisms and initiating complement fixation through an N-terminal collagen-like domain. MBL is a key component of immune defense and can neutralize invading microorganisms via an antibody-independent mechanism.
Mutations in human MBL are associated with immunodeficiency due to reduced complement activation. In humans, MBL-associated serine proteases (MASP-1, MASP-2, MASP-3) and a truncated form of MASP-2 (sMAP or MAp19) complex with MBL to activate the lectin pathway. Activated MASPs cleave and activate downstream complement components. MASP-3, an alternatively spliced product of MASP-1, may inhibit MASP-2 by competing for MBL binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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