Thermo Fisher Scientific MASP2 Polyclonal Antibody
MASP2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. 인간 시료에 반응하며, 고순도 Affinity Chromatography로 정제. 연구용으로 면역 반응 및 보체 경로 연구에 적합.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific MASP2 Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human MASP2 (aa 35–84) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2610544 |
Product Specific Information
- Peptide sequence: FPGEYANDQE RRWTLTAPPG YRLRLYFTHF DLELSHLCEY DFVKLSSGAK
- Sequence homology:
- Cow: 100%
- Dog: 100%
- Guinea Pig: 100%
- Horse: 100%
- Human: 100%
- Mouse: 100%
- Rat: 100%
- Zebrafish: 77%
Target Information
Mannose (or mannan)-binding lectin (MBL), also known as serum mannose-binding protein (MBP), initiates the lectin branch of the innate immune response by binding to the surface of pathogenic microorganisms and initiating complement fixation through an N-terminal collagen-like domain. MBL is a key component of immune defense and can neutralize invading microorganisms via an antibody-independent mechanism.
Mutations in human MBL are associated with immunodeficiency due to reduced complement activation. In humans, MBL-associated serine proteases (MASP-1, MASP-2, MASP-3) and a truncated form of MASP-2 (sMAP or MAp19) complex with MBL to activate the lectin pathway. Activated MASPs cleave and activate downstream complement components. MASP-3, an alternatively spliced product of MASP-1, may inhibit MASP-2 by competing for MBL binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(해당 제품 관련 이미지는 Thermo Fisher Scientific 제공 이미지로 하단에 배치됩니다.)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.