Thermo Fisher Scientific CHRM2 Monoclonal Antibody (4B5)
CHRM2 단백질을 표적으로 하는 Mouse IgG2a 단클론 항체로, Western Blot 및 ELISA에 최적화됨. 인간 종에 반응하며 액상 형태로 제공. PBS 버퍼에 보존제 없이 -20°C에서 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 0.03 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4B5 |
| Immunogen | CHRM2 (AAI06743.1, 251–350 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
SDDGLEHNKI QNGKAPRDPV TENCVQGEEK ESSNDSTSVS AVASNMRDDE ITQDENTVST SLGHSKDENS KQTCIRIGTK TPKSDSCTPT NTTVEVVGSS
Target Information
Muscarinic cholinergic receptor 2 (CHRM2) is an acetylcholine receptor suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release. The M2 receptor may mediate smooth muscle contractility. In Alzheimer’s disease, selective loss of M2 subtype receptors occurs in cortical and hippocampal regions. Increased M2 receptor heterozygosity has been associated with depression in women. The M2 receptor is expressed in various brain regions (cerebellum, cerebral cortex, hippocampus, medulla, striatum, thalamus) as well as in lung and prostate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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