Thermo Fisher Scientific BIKE Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200

Product Specifications

Product Specific Information

• Immunogen sequence:
  FISHSGSPEK KAEHSSINQE NGTANPIKNG KTSPASKDQR TGKKTSVQGQ VQKGNDESES DFESDPPSPK SSEEEEQDDE EV
• Highest antigen sequence identity to orthologs:
  Mouse - 66%, Rat - 65%

Target Information

The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis, and apoptosis.
Serine/threonine (Ser/Thr) protein kinases, including BMP2K (BMP2 inducible kinase, also known as BIKE), are involved in these processes.
BIKE is a 1,161 amino acid nuclear protein containing one protein kinase domain and belongs to the Ser/Thr protein kinase family.
It is thought to be involved in osteoblast differentiation and catalyzes ATP-dependent phosphorylation of bone morphogenic proteins (BMPs), which are essential for cartilage and bone formation.
Through its catalytic activity, BMP2K may play a role in signaling pathways that mediate bone growth and cellular differentiation.
Three isoforms of BMP2K exist due to alternative splicing events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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