Thermo Fisher Scientific alpha Actinin 2 Polyclonal Antibody

Applications

• Western Blot (WB): 1:1,000–1:3,000

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total ACTN2.

Target Information

Alpha actinins belong to the spectrin gene superfamily, representing a diverse group of cytoskeletal proteins, including alpha and beta spectrins and dystrophins.
Alpha actinin is an actin-binding protein with multiple roles in different cell types.

• In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it binds actin to the membrane.
• In skeletal, cardiac, and smooth muscle, isoforms are localized to the Z-disc and dense bodies, anchoring myofibrillar actin filaments.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.