ELK Biotechnology Caspase-1 rabbit pAb
Caspase-1 rabbit pAb는 인간, 마우스, 랫트에 반응하는 폴리클로날 항체로, 세포사멸 연구에 적합합니다. IF, WB, IHC, ELISA에 사용 가능하며 고순도 IgG 형태로 제공됩니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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Caspase-1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Caspase-1 rabbit pAb |
| Alternative Names | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) |
| Applications | IF; WB; IHC; ELISA |
| Recommended Dilutions | IF: 1:50–200; WB: 1:500–2000; IHC: 1:50–300; ELISA: 1:10000–20000 |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human CASP1. AA range: 350–400 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 45 kD |
| GeneID (Human) | 834 |
| Human Swiss-Prot No | P29466 |
| Cellular Localization | Cytoplasm, Cell membrane |
| Species Reactivity | Human, Mouse, Rat |
Background
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme.
This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in inflammation, septic shock, and wound healing. It has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
[provided by RefSeq, Mar 2012]
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