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ELK Biotechnology TAL1/2 (Acetyl Lys221/Acetyl Lys222/Acetyl Lys36/Acetyl Lys37) rabbit pAb
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ELK Biotechnology

ELK Biotechnology TAL1/2 (Acetyl Lys221/Acetyl Lys222/Acetyl Lys36/Acetyl Lys37) rabbit pAb

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TAL1/2 단백질의 아세틸화 부위를 인식하는 토끼 폴리클로날 항체로, WB와 ELISA에 적합합니다. 핵 내 단백질 검출에 유용하며, 혈액세포 분화 및 백혈병 관련 연구에 활용 가능합니다. -20°C에서 1년 보관 가능합니다.

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ELK Biotechnology
카테고리
Polyclonal Antibodies
판매단위
pk
#ELK Biotechnology#Polyclonal Antibodies#Antibodies

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ELK Biotechnology ES8436-100UL TAL1/2 (Acetyl Lys221/Acetyl Lys222/Acetyl Lys36/Acetyl Lys37) rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES8436-50UL TAL1/2 (Acetyl Lys221/Acetyl Lys222/Acetyl Lys36/Acetyl Lys37) rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원
재고문의·견적요청 옵션은 실시간 상담으로 납기를 확인해 드립니다 · 연구비 카드 결제 가능

ELK Biotechnology · ELK Biotechnology TAL1/2 (Acetyl Lys221/Acetyl Lys222/Acetyl Lys36/Acetyl Lys37) rabbit pAb

제품명

TAL1/2 (Acetyl Lys221/Acetyl Lys222/Acetyl Lys36/Acetyl Lys37) rabbit pAb

제품 정보

항목 내용
Alternative Names TAL1; BHLHA17; SCL; TCL5; T-cell acute lymphocytic leukemia protein 1; TAL-1; Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia/lymphoma protein 5; TAL2; BHLHA19; T-cell acute lymphocytic leukemia protein 2; TAL-2; Class A basic helix-loop-helix protein 19; bHLHa19
Applications WB; ELISA
Recommended Dilutions Western Blot: 1/500 - 1/2000
ELISA: 1/10000
Other applications not yet tested
Immunogen Synthesized acetyl-peptide derived from human TAL1/2 around the acetylation site of K221
Host Rabbit
Storage -20°C / 1 year
Clonality Polyclonal
Isotype IgG
Concentration 1 mg/ml
Observed Band 45 kDa
Gene ID (Human) 6886
Human Swiss-Prot No P17542
Cellular Localization Nucleus
Species Reactivity Human; Mouse; Rat

Background

The splicing pattern of TAL1/2 is cell-lineage dependent.
A chromosomal aberration involving TAL1 may cause certain T-cell acute lymphoblastic leukemias (T-ALL), particularly the translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.

  • Domain: The helix-loop-helix domain is necessary and sufficient for interaction with DRG1.
  • Function: Implicated in the genesis of hematopoietic malignancies; may play an important role in hematopoietic differentiation and act as a positive regulator of erythroid differentiation.
  • Post-translational Modifications (PTM):
    • Phosphorylated on serine residues (notably Ser-122 under hypoxia).
    • Ubiquitinated following hypoxia-dependent phosphorylation of Ser-122, leading to rapid degradation via the ubiquitin system (not observed in large vessel endothelial cells).
  • Similarity: Contains one basic helix-loop-helix (bHLH) domain.
  • Subunit: DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3 and binds to LMO2 and DRG1. Can assemble in a complex with LDB1 and LMO2 (TAL-1 complex: CBFA2T3, LDB1, TAL1, TCF3).
  • Tissue Specificity: Leukemic stem cell.

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