ELK Biotechnology p300 (Acetyl Lys1558/Acetyl Lys1560) rabbit pAb
p300 단백질의 Acetyl Lys1558/1560 부위를 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간, 생쥐, 랫트 시료에 반응하며, 세포 내 전사 조절 및 히스톤 아세틸화 연구에 유용합니다. -20°C에서 1년 보관 가능합니다.
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제품명
p300 (Acetyl Lys1558/Acetyl Lys1560) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | EP300; P300; Histone acetyltransferase p300; p300 HAT; E1A-associated protein p300 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized acetyl-peptide derived from human p300 around the acetylation site of K1558 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 300 kD |
| Gene ID (Human) | 2033 |
| Human Swiss-Prot No. | Q09472 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm, Nucleus, Chromosome. Localizes to active chromatin and colocalizes with histone H3 acetylated or crotonylated at Lys-18 (H3K18ac, H3K18cr). In presence of ALX1, relocalizes from cytoplasm to nucleus; colocalizes with ROCK2 in nucleus. |
Background
E1A binding protein p300 (EP300) is a transcriptional co-activator associated with adenovirus E1A. It functions as a histone acetyltransferase that regulates transcription via chromatin remodeling and plays a key role in cell proliferation and differentiation. EP300 mediates cAMP-gene regulation by binding phosphorylated CREB protein and acts as a co-activator of HIF1A, contributing to hypoxia-induced gene expression such as VEGF. Mutations in this gene are associated with Rubinstein-Taybi syndrome and may contribute to epithelial cancers. (RefSeq, Jul 2008)
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