ELK Biotechnology p53 (Mono Methyl Lys370) rabbit pAb

제품명

p53 (Mono Methyl Lys370) rabbit pAb

공급업체

ELK Biotechnology

제품 개요

이 항체는 인간 p53 단백질의 K370 mono-methylation 부위에서 유래한 합성 펩타이드를 면역원으로 사용하여 제작된 rabbit polyclonal 항체입니다. 세포 스트레스 반응, DNA 손상 및 종양 억제 기전 연구에 활용할 수 있습니다.

제품 스펙

세포 내 위치 (Cellular Localization)

• Cytoplasm, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix
• Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
• Recruited into PML bodies together with CHEK2 (PubMed:12810724)
• Translocates to mitochondria upon oxidative stress (PubMed:22726440)
• Translocates to mitochondria in response to mitomycin C treatment (PubMed:27323408)
• Isoform 1: Predominantly nuclear, but localizes to cytoplasm when expressed with isoform 4
• Isoform 2: Mainly nuclear with minor cytoplasmic staining
• Isoform 3: Nuclear in most cells, cytoplasmic in some cells
• Isoform 4: Predominantly nuclear but translocates to cytoplasm

Background

Tumor protein p53 (TP53) Homo sapiens
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or metabolic changes. Mutations in this gene are associated with various human cancers, including hereditary cancers such as Li-Fraumeni syndrome.
Alternative splicing and use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms may result from alternate translation initiation codons (PMIDs: 12032546, 20937277). [Provided by RefSeq, Feb 2013]