ELK Biotechnology ASAH3 rabbit pAb
ASAH3 단백질을 인식하는 토끼 폴리클로날 항체로, WB와 ELISA에 사용 가능. 세라마이드 대사 관련 연구에 적합하며, 고순도 IgG 형식으로 제공. -20°C에서 1년간 안정적으로 보관 가능.
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제품명
ASAH3 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ACER1; ASAH3; Alkaline ceramidase 1; AlkCDase 1; Alkaline CDase 1; Acylsphingosine deacylase 3; N-acylsphingosine amidohydrolase 3 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from ASAH3 (AA range: 100-180) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 34 kD |
| GeneID (Human) | 125981 |
| Human Swiss-Prot No | Q8TDN7 |
| Cellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Species Reactivity | Human; Rat; Mouse |
Background
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]). [Supplied by OMIM, Jul 2010]
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