ELK Biotechnology MB67 rabbit pAb

제품명

MB67 rabbit pAb

제품 개요

NR1I3(CAR, Constitutive androstane receptor)에 대한 토끼 폴리클로날 항체로, 핵 수용체 연구 및 약물 대사 관련 단백질 분석에 적합합니다.

주요 정보

Background

This gene encodes a member of the nuclear receptor superfamily and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds DNA as a monomer or heterodimer with the retinoid X receptor and regulates transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been identified (RefSeq, Jul 2008).