ELK Biotechnology Cdc25A (phospho Ser75) rabbit pAb
Cdc25A (phospho Ser75) rabbit polyclonal antibody로, 인간 CDC25A의 Ser75 인산화 부위를 인식합니다. WB 및 ELISA에 적합하며, 세포 내 핵 및 세포질에서 발현되는 단백질 검출에 사용됩니다. 고순도 IgG, 1 mg/ml 농도, -20°C 보관.
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제품명
Cdc25A (phospho Ser75) rabbit pAb
공급업체
ELK Biotechnology
제품 개요
Cdc25A (phospho Ser75) rabbit polyclonal antibody는 인간 CDC25A 단백질의 Ser75 인산화 부위를 특이적으로 인식하도록 제작된 항체입니다. 세포 주기 조절 및 DNA 손상 반응 연구에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CDC25A; M-phase inducer phosphatase 1; Dual specificity phosphatase Cdc25A |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human CDC25A around the phosphorylation site of Ser75 (AA range: 43–92) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kD |
| GeneID (Human) | 993 |
| Human Swiss-Prot No | P30304 |
| Cellular Localization | Intracellular, nucleus, nucleoplasm, cytoplasm, cytosol |
| Species Reactivity | Human; Mouse; Rat |
Background
Cell division cycle 25A (CDC25A) is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to S phase of the cell cycle and activates cyclin-dependent kinase CDC2 by removing two phosphate groups. It is specifically degraded in response to DNA damage, preventing cells with chromosomal abnormalities from dividing. CDC25A is considered an oncogene, although its exact role in oncogenesis has not been fully demonstrated. Two transcript variants encoding different isoforms have been identified for this gene. [RefSeq, Jul 2008]
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