ELK Biotechnology TBC1D4 rabbit pAb

제품명

TBC1D4 rabbit pAb

대체 명칭

TBC1D4; AS160; KIAA0603; TBC1 domain family member 4; Akt substrate of 160 kDa; AS160

적용 분야 (Applications)

• Immunohistochemistry (IHC)
• Immunofluorescence (IF)
• ELISA

권장 희석 배수 (Recommended Dilutions)

면역원 (Immunogen)

The antiserum was produced against synthesized peptide derived from human AS160.
AA range: 611–660

보관 및 안정성 (Storage)

• 종(species): Rabbit
• 보관 조건: -20°C, 1년 안정

항체 특성 (Antibody Properties)

유전자 정보 (Gene Information)

세포 내 위치 (Cellular Localization)

Cytoplasm. Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.

배경 (Background)

This gene is a member of the Tre-2/BUB2/CDC16 domain family. The encoded protein is a Rab-GTPase-activating protein containing two phosphotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs.
It plays an important role in glucose homeostasis by regulating insulin-dependent trafficking of the glucose transporter 4 (GLUT4), essential for glucose uptake into skeletal muscle and adipose tissue. Reduced expression increases GLUT4 levels at the plasma membrane, indicating its role in intracellular retention of GLUT4 under basal conditions. Upon insulin stimulation, the protein becomes phosphorylated, dissociates from GLUT4 vesicles, leading to increased surface GLUT4 and enhanced glucose transport.

반응 종 (Species Reactivity)

Human; Mouse