ELK Biotechnology TBC1D4 (phospho Thr642) rabbit pAb
TBC1D4 (phospho Thr642) rabbit polyclonal antibody로 인간 및 마우스 시료에 반응. WB, IHC, IF, ELISA에 사용 가능. 인슐린 신호 관련 GLUT4 조절 연구에 적합. 고순도 IgG 형식으로 -20°C에서 1년 보관 가능.
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제품명
TBC1D4 (phospho Thr642) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TBC1D4; AS160; KIAA0603; TBC1 domain family member 4; Akt substrate of 160 kDa; AS160 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | IHC: 1/100 - 1/300 IF: 1/200 - 1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human AS160 around phosphorylation site of Thr642 (AA range: 611–660) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 150 kDa |
| GeneID (Human) | 9882 |
| Human Swiss-Prot No | O60343 |
| Species Reactivity | Human; Mouse |
| Cellular Localization | Cytoplasm. Isoform 2 shows cytoplasmic perinuclear localization in myoblastic cells under resting and insulin-stimulated conditions. |
Background
This gene belongs to the Tre-2/BUB2/CDC16 domain family. The encoded protein is a Rab-GTPase-activating protein containing two phosphotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs.
It plays an essential role in glucose homeostasis by regulating insulin-dependent trafficking of GLUT4, which mediates glucose uptake into skeletal muscle and adipose tissue.
Reduced expression increases GLUT4 at the plasma membrane, indicating its role in intracellular GLUT4 retention under basal conditions. Upon insulin stimulation, the protein is phosphorylated, dissociates from GLUT4 vesicles, and promotes glucose transport.
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