ELK Biotechnology Gab 2 (phospho Ser623) rabbit pAb
Gab2 단백질의 Ser623 인산화 부위를 인식하는 토끼 다클론 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 생쥐, 랫트 반응성. 세포막 및 세포질 위치 단백질 검출에 적합. -20°C에서 1년 보관 가능.
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제품명
Gab 2 (phospho Ser623) rabbit pAb
대체 명칭
GAB2; KIAA0571; GRB2-associated-binding protein 2; GRB2-associated binder 2; Growth factor receptor bound protein 2-associated protein 2; pp100
적용 분야 (Applications)
WB; IHC; IF; ELISA
권장 희석 배수 (Recommended Dilutions)
- Western Blot: 1/500 - 1/2000
- Immunohistochemistry: 1/100 - 1/300
- ELISA: 1/5000
- Other applications: Not yet tested
면역원 (Immunogen)
The antiserum was produced against synthesized peptide derived from human Gab2 around the phosphorylation site of Ser623.
Amino acid range: 589–638
제품 사양 (Specifications)
| 항목 | 내용 |
|---|---|
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 80 kD |
| Gene ID (Human) | 9846 |
| Human Swiss-Prot No. | Q9UQC2 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm; Cell membrane |
| Storage Condition | -20°C / 1 year |
배경 (Background)
GRB2 associated binding protein 2 (GAB2) is a member of the GRB2-associated binding protein (GAB) family. These proteins contain a pleckstrin homology (PH) domain and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [Provided by RefSeq, Nov 2009]
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