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ELK Biotechnology ERI1 rabbit pAb
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ELK Biotechnology ERI1 rabbit pAb

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ERI1 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot 및 ELISA에 사용 가능. 인간 유래 합성 펩타이드로 면역화되어 높은 특이성과 재현성을 제공. 세포질 및 핵에 발현되는 ERI1 단백질 검출에 적합.

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pk
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ELK Biotechnology ES7939-100UL ERI1 rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES7939-50UL ERI1 rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원

ELK Biotechnology · ELK Biotechnology ERI1 rabbit pAb

제품명

ERI1 rabbit pAb

제품 정보

항목 내용
Alternative Names ERI1; 3EXO; THEX1; 3-5exoribonuclease 1; 3-5exonuclease ERI1; Eri-1 homolog; Histone mRNA 3-end-specific exoribonuclease; Histone mRNA 3-exonuclease 1; Protein 3hExo; HEXO
Applications WB; ELISA
Recommended Dilutions Western Blot: 1/500 - 1/2000
ELISA: 1/5000
Not yet tested in other applications
Immunogen Synthesized peptide derived from human ERI1 (AA range: 261-310)
Host Rabbit
Storage -20°C, 1 year
Clonality Polyclonal
Isotype IgG
Concentration 1 mg/ml
Observed Band 37 kDa
Gene ID (Human) 90459
Human Swiss-Prot No. Q8IV48
Cellular Localization Cytoplasm, Nucleus, Nucleolus
Species Reactivity Human, Mouse, Rat

Background

  • Cofactor: Binds 2 magnesium ions per subunit.
  • Enzyme Regulation: Although it can bind simultaneously with SLBP to the 3'-end of histone mRNA, the presence of SLBP prevents the exonuclease activity.
  • Function: RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, playing an essential role in histone mRNA decay after replication. Also degrades 3'-overhangs of siRNAs in vitro, suggesting a role in RNA interference (RNAi) regulation. Required for 5.8S rRNA 3'-end processing.
  • Sequence Caution: Translated as Leu.
  • Similarity: Contains 1 exonuclease domain and 1 SAP domain.
  • Subunit Interaction: Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs, requiring the 5'-ACCCA-3' sequence. Also binds to ribosomal subunits (40S, 60S) and 80S assembled ribosomes, as well as 5.8S rRNA.

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