ELK Biotechnology SKI-1 rabbit pAb

제품명

SKI-1 rabbit pAb

공급업체

ELK Biotechnology

제품 설명

SKI-1 rabbit pAb는 subtilisin-like proprotein convertase 계열 단백질을 인식하는 다클론 항체로, 단백질 전구체의 처리 및 지질 항상성 조절 연구에 사용됩니다. 인간, 마우스, 랫트 시료에서 반응하며, 다양한 면역학적 분석에 적합합니다.

주요 특성 및 응용

• 응용 분야: WB, ELISA, IHC
• 반응 종(species reactivity): Human, Mouse, Rat
• 단백질 위치: Endoplasmic reticulum membrane, Golgi apparatus membrane, lysosomal/endosomal compartments

권장 희석 배율

• WB: 1:500–2000
• IHC-p: 1:50–300
• ELISA: 1:2000–20000

기술 사양

Background

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane-bound protease that regulates cholesterol and lipid homeostasis via cleavage of substrates at non-basic residues. Mutations may be associated with lysosomal dysfunction. (RefSeq, Feb 2014)