ELK Biotechnology Caspase-9 (phospho Tyr153) rabbit pAb
Caspase-9 (phospho Tyr153) rabbit pAb는 인간 Caspase-9의 Tyr153 인산화 부위를 인식하는 폴리클로날 항체입니다. WB, IF, ELISA에 사용 가능하며, 세포 사멸 연구에 적합합니다. 인간, 랫드, 마우스 시료에 반응하며, -20°C에서 1년 보관 가능합니다.
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Caspase-9 (phospho Tyr153) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Caspase-9 (phospho Tyr153) rabbit pAb |
| Alternative Names | CASP9; MCH6; Caspase-9; CASP-9; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; APAF-3; ICE-like apoptotic protease 6; ICE-LAP6 |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Caspase 9 around the phosphorylation site of Tyr153 (AA range: 119–168) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 46 kDa |
| GeneID (Human) | 842 |
| Human Swiss-Prot No | P55211 |
| Cellular Localization | Nucleus, mitochondrion, cytosol, apoptosome |
| Species Reactivity | Human; Rat; Mouse |
Background
CASP9 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits (large and small) that dimerize to form the active enzyme. Caspase-9 can undergo autoproteolytic processing and activation by the apoptosome, a complex of cytochrome c and apoptotic peptidase activating factor 1. This step is one of the earliest in the caspase activation cascade. Caspase-9 is thought to play a central role in apoptosis and act as a tumor suppressor. Alternative splicing results in multiple transcript variants.
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