Thermo Fisher Scientific CD103 Monoclonal Antibody (AX.14), PE
인간 CD103(Integrin αE) 인식 단일클론 항체로 PE 형광 표지되어 있으며, 유세포 분석(Flow Cytometry)에 적합합니다. Protein A/G 정제, PBS 버퍼에 보관되며 4°C에서 안정적입니다. 연구용으로만 사용 가능합니다.
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Applications
- Flow Cytometry (Flow)
Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AX.14 |
| Immunogen | White blood cells |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.2% carrier protein |
| Contains | 0.08% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1075349 |
Additional Formats
Target Information
CD103 (ITGAE, Integrin alpha E) is expressed on mucosa-associated T lymphocytes, activated cells, and a subset of TGF-β1 cells. It comprises a 150 kDa alpha chain and a 120 kDa beta chain. CD103 is expressed by 0.5–2% of resting lymphocytes in peripheral blood and lymphoid organs. The antibody stains a few bone marrow cells and rarely peripheral blood lymphocytes.
CD103 belongs to the integrin family—heterodimeric integral membrane proteins composed of alpha and beta chains. ITGAE encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage, forming disulfide-linked heavy and light chains. Together with beta 7 integrin, CD103 forms the E-cadherin binding integrin known as human mucosal lymphocyte-1 antigen. It is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL) and may function in adhesion and IEL activation.
Diseases associated with CD103 dysfunction include hairy cell leukemia and splenic marginal zone lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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