Thermo Fisher Scientific CD53 (TSPAN25) Monoclonal Antibody (161-2)
CD53 (TSPAN25) 단백질을 인식하는 mouse monoclonal antibody로, 인간 시료에 반응합니다. ICC/IF, Flow Cytometry, Functional Assay 등 다양한 응용에 사용 가능하며, Protein A/G로 정제된 액상 형태입니다. 4°C 보관, 동결 금지.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| Functional Assay (Functional) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 161-2 |
| Immunogen | Stimulated human leukocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Baboon or Horse
Target Information
CD53 is a tetraspanin family transmembrane glycoprotein expressed in the lymphoid-myeloid lineage.
It forms complexes with other leukocyte surface proteins such as CD2, CD19, CD21, MHC II, VLA-4, and tetraspanins CD37, CD81, CD82, modulating various signaling processes.
CD53 contributes to tumor cell radioresistance and has anti-apoptotic effects upon activation.
In thymus, CD53 is up-regulated during T cell development and strongly expressed upon macrophage exposure to bacterial lipopolysaccharide, while neutrophil stimulation down-regulates CD53 expression.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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