Thermo Fisher Scientific COPS6 Monoclonal Antibody (OTI4E7), TrueMAB
COPS6 단백질을 표적하는 Mouse monoclonal 항체로, Western blot, IHC, ICC/IF에 사용 가능. Human 시료 반응성, Lyophilized 형태로 제공되며, 고순도 affinity chromatography 정제. 연구용으로 세포 신호 및 단백질 조절 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4E7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 58–327 of human COPS6 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
COPS6 is one of the eight subunits of the COP9 signalosome, a conserved protein complex that regulates multiple signaling pathways. Its structure and function are similar to the 19S regulatory particle of the 26S proteasome. COP9 signalosome interacts with SCF-type E3 ubiquitin ligases and acts as a positive regulator. The protein belongs to the translation initiation factor 3 superfamily, involved in cell cycle regulation and may serve as a cofactor for HIV-1 accessory gene product Vpr.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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