Thermo Fisher Scientific PREB Polyclonal Antibody
PREB 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, WB 및 IHC(P) 적용 가능. N-말단 합성 펩타이드로 면역화되어 높은 특이성과 재현성을 제공. 인간 반응성, 액상 형태, -20°C 보관. 연구용으로만 사용.
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 4–8 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human PREB (aa 140–189) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2577171 |
Product Specific Information
- Peptide sequence: RVENLQAVQT DFSSDPLQKV VCFNHDNTLL ATGGTDGYVR VWKVPSLEKV
- Sequence homology:
- Cow: 83%
- Dog: 92%
- Guinea Pig: 91%
- Horse: 100%
- Human: 100%
- Mouse: 83%
- Pig: 100%
- Rabbit: 100%
- Rat: 100%
Target Information
Prolactin (PRL) expression in the pituitary is limited to specific cells. Pit-1 is a pituitary-specific transcription factor that plays an important role in PRL expression, both in mature organisms and during development. The PRL promoter contains numerous Pit-1 binding sites implicated in both basal and kinase-mediated gene expression. The most proximal site, termed 1P, responds to signals such as cAMP and various G-proteins. PREB (prolactin regulatory element binding protein) regulates PRL gene expression through the 1P site, despite lacking a DNA-binding motif. Studies show PREB is encoded by a single-copy gene in mice and humans and accumulates in pituitary cell nuclei, acting as a novel transcription factor assisting PRL expression alone or with Pit-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
- PA5-40828_PREB_Q9HCU5-1_Rabbit.svg
- PA5-40828_PREB_Q9HCU5-1_Rabbit_PDP.jpeg
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