Thermo Fisher Scientific NR1H3 Monoclonal Antibody (OTI1F5), TrueMAB
Human NR1H3(LXR-alpha) 단백질을 인식하는 Mouse monoclonal antibody로 Western blot에 최적화됨. Unconjugated 형태이며 1 mg/mL 농도, PBS/BSA/glycerol buffer에 보관. 콜레스테롤 항상성 연구 및 핵수용체 신호전달 분석에 적합.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 69–329 of human NR1H3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from a silent DNA-binding partner to an active ligand-binding subunit, mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides.
NR1H3 plays an important role in the regulation of cholesterol homeostasis, controlling cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interacts functionally with RORA to regulate genes involved in liver metabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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