Thermo Fisher Scientific AKAP95/AKAP8 Polyclonal Antibody
AKAP95/AKAP8 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체입니다. IHC, ICC, ELISA 등 다양한 응용에 적합하며, Human, Mouse, Rat에 반응합니다. Protein A로 정제된 액상 제품으로, -20°C에서 보관합니다.
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human AKAP95, amino acids 401–550 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is mediated by compartmentalization of the kinase within the cell. The R subunit (RII) of PKA interacts with specific RII-anchoring proteins, designated as A-kinase anchoring proteins (AKAPs).
AKAP95 (also known as AKAP8) is a nuclear matrix protein predominantly expressed in liver, heart, pancreas, kidney, and skeletal muscle. During mitosis, AKAP95 is recruited to chromosomes and plays an essential role in mitotic progression. It participates in PKA signaling through interaction with the RII regulatory subunit and forms a complex with HA95 and HDAC3, which is required for deacetylation of Histone H3 in mitosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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