Thermo Fisher Scientific C12orf66 Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human C12orf66 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:C12orf66,uniProtId:Q96MD2-1,ncbiNodeId:9606,antigenRange:176-271,antigenLength:445,antigenImageFileName:PA5-61303_C12orf66_Q96MD2-1_Rabbit.svg,antigenImageFileNamePDP:PA5-61303_C12orf66_Q96MD2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2638737

Product Specific Information

Immunogen sequence: HHPILSPLES SFQLEVDVLC HLLKAQAQVS EWKFLPSLVN LHSAHTKLQT WGQIFEKQRE TKKHLFGGQS QKAVQPPHLF LWLMKLKNML LAKFSF

Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.

Target Information

As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.