Thermo Fisher Scientific C12orf66 Polyclonal Antibody
Rabbit polyclonal antibody targeting Human C12orf66 protein. Functions as part of the KICSTOR complex regulating mTORC1 signaling. Supplied unconjugated in liquid form at 0.05 mg/mL. For research use only.
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Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human C12orf66 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638737 |
Product Specific Information
Immunogen sequence:
HHPILSPLES SFQLEVDVLC HLLKAQAQVS EWKFLPSLVN LHSAHTKLQT WGQIFEKQRE TKKHLFGGQS QKAVQPPHLF LWLMKLKNML LAKFSF
Antigen sequence identity:
- Mouse: 92%
- Rat: 92%
Target Information
C12orf66 functions as part of the KICSTOR complex in the amino acid-sensing branch of the TORC1 signaling pathway.
It recruits the GATOR1 complex to lysosomal membranes, enabling its interaction with GATOR2 and RAG GTPases.
Acts upstream of RAG GTPases and negatively regulates mTORC1 signaling in the absence of amino acids.
Without the KICSTOR complex, mTORC1 remains constitutively localized to the lysosome and activated.
The KICSTOR complex may also participate in glucose-dependent regulation of mTORC1.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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