Thermo Fisher Scientific TRRAP Polyclonal Antibody
TRRAP 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, ICC/IF, IP, ChIP 등 다양한 응용에 적합합니다. 인간 시료에 반응하며, 예측 반응성은 마우스, 랫, 소 등에서도 높습니다. 항원 친화 크로마토그래피로 정제된 액상 제품입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
| Immunoprecipitation (IP) | 1:100–1:500 |
| ChIP assay (ChIP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the N-terminus region of human TRRAP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792720 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (98%), Rat (98%), Japanese Medaka (91%), Bovine (100%).
- Positive Control: Jurkat, Raji, NCI-H929, 293T, A431, HeLa, HepG2.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TRRAP is an adapter protein found in various multiprotein chromatin complexes with histone acetyltransferase (HAT) activity, contributing to epigenetic transcription activation. It is a component of the NuA4 HAT complex responsible for acetylation of nucleosomal histones H4 and H2A.
TRRAP plays a central role in MYC transcription activation and participates in cell transformation by MYC. It is required for p53/TP53-, E2F1-, and E2F4-mediated transcription activation and is also involved in transcription activation mediated by the adenovirus E1A oncoprotein.
TRRAP likely links transcription factors such as E1A, MYC, or E2F1 to HAT complexes such as STAGA, enabling transcription activation. It may also be required for the mitotic checkpoint and normal cell cycle progression.
Additionally, TRRAP is a component of a SWR1-like complex that mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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