Thermo Fisher Scientific IPO9 Polyclonal Antibody
Thermo Fisher Scientific IPO9 Polyclonal Antibody는 인간 Importin-9(991–1041) 영역을 인식하는 Rabbit IgG 폴리클로날 항체입니다. Western blot 및 Immunoprecipitation에 적합하며, 핵 단백질 수송 연구에 활용됩니다. 액상 형태로 제공되며 4°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,500
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 991 to 1041 of human Importin-9 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
Functions in nuclear protein import as a nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin, followed by translocation through the pore via a Ran-dependent mechanism.
At the nucleoplasmic side of the NPC, Ran binds to importin, causing dissociation of the complex and re-export of importin to the cytoplasm. The directionality of nuclear import is maintained by asymmetric distribution of GTP- and GDP-bound forms of Ran between cytoplasm and nucleus.
Mediates nuclear import of H2B histone, RPS7, and RPL18A, and prevents cytoplasmic aggregation by shielding exposed basic domains. May also import H2A, H3, H4 histones, RPL4, and RPL6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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