Thermo Fisher Scientific SLUG Monoclonal Antibody (OTI1G7)
SLUG 단백질을 표적하는 Thermo Fisher Scientific의 Mouse IgG1 단일클론 항체. Western blot, IHC, ICC/IF, Flow cytometry에 사용 가능. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 1 mg/mL 농도. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G7 |
| Immunogen | Full length human recombinant protein of SNAI2 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725367 |
Target Information
Slug (SNAI2), a member of the Snail family of C2H2-type zinc finger transcription factors, is involved in epithelial-mesenchymal transitions and neural tube formation during vertebrate embryogenesis. Its transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Slug binds E-box regions of promoters and represses transcription of genes like E-cadherin and Claudin-1. Expression of Slug in breast, esophageal, and colorectal carcinomas correlates with poor prognosis. It also protects hematopoietic progenitor cells from radiation-induced apoptosis by repressing p53-mediated transcription of Puma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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