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ELK Biotechnology SHIP2 (phospho-Tyr1135) rabbit pAb
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SHIP2 (phospho-Tyr1135) rabbit pAb는 인슐린 기능 조절 및 세포골격 재구성 연구에 적합한 다클론 항체입니다. WB, IF, ELISA, IHC에 사용 가능하며, 사람, 생쥐, 랫드에 반응합니다. 세포막 및 세포질 내 SHIP2 인산화 단백질 검출에 유용합니다.
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- pk
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ELK Biotechnology ES13121-100UL SHIP2 (phospho-Tyr1135) rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES13121-50UL SHIP2 (phospho-Tyr1135) rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology SHIP2 (phospho-Tyr1135) rabbit pAb
제품명
SHIP2 (phospho-Tyr1135) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (EC 3.1.3.86); Inositol polyphosphate phosphatase-like protein 1 (INPPL-1); Protein 51C; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SHIP-2 |
| Applications | WB; IF; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IF/ICC 1:50–200; ELISA 1:2000–20000; IHC-p 1:50–200 |
| Immunogen | Synthesized phospho peptide around human SHIP2 (Tyr1135) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 130 kD |
| Gene ID (Human) | 3636 |
| Human Swiss-Prot No. | O15357 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Cytoplasm, cytosol; Cytoplasm, cytoskeleton; Membrane (Peripheral membrane protein); Cell projection (filopodium, lamellipodium); Nucleus; Nucleus speckle. Translocates to membrane ruffles when activated, partly via SH2 domain interaction with phosphorylated receptors such as FCGR2B. Insulin stimulates redistribution to plasma membrane. Recruited to membrane following M-CSF stimulation. In activated spreading platelets, localizes with actin at filopodia, lamellipodia, and the central actin ring. |
Background
The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase involved in insulin function regulation. It also regulates epidermal growth factor receptor turnover and actin remodeling. Additionally, this gene supports metastatic growth in breast cancer and serves as a valuable biomarker for breast cancer.
[Provided by RefSeq, Jan 2009]
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