ELK Biotechnology Smad1 (phospho-Ser206) rabbit pAb
Smad1 단백질의 인산화 부위(Ser206)를 인식하는 토끼 폴리클로날 항체. WB 및 IHC에 적합하며, BMP 신호전달 경로 연구에 활용 가능. 인산화된 Smad1 검출에 특이적이며, 세포 내 위치 연구에 유용.
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제품명
Smad1 (phospho-Ser206) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Mothers against decapentaplegic homolog 1 (MAD homolog 1), Mothers against DPP homolog 1, JV4-1, Mad-related protein 1, SMAD family member 1, SMAD1, Smad1, hSMAD1, Transforming growth factor-beta-signaling protein 1, BSP-1 |
| Applications | WB; IHC |
| Recommended Dilutions | WB: 1:500–2000; IHC-p: 1:50–300 |
| Immunogen | Synthesized phospho peptide around human Smad1 (Ser206) |
| Host Species | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 52 kDa |
| Gene ID (Human) | 4086 |
| Human Swiss-Prot No. | Q15797 |
| Species Reactivity | Human, Rat, Mouse |
| Cellular Localization | Cytoplasm and nucleus. Cytoplasmic in the absence of ligand; migrates to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane. Exported from the nucleus to the cytoplasm when dephosphorylated. |
Background
The protein encoded by this gene belongs to the SMAD family, which includes proteins similar to the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators mediating multiple signaling pathways. This protein mediates bone morphogenetic protein (BMP) signals, which regulate cell growth, apoptosis, morphogenesis, development, and immune responses. Upon BMP ligand binding, this protein is phosphorylated and activated by BMP receptor kinase. The phosphorylated form forms a complex with SMAD4, essential for transcriptional regulation. It is also a target of SMAD-specific E3 ubiquitin ligases (SMURF1, SMURF2), leading to ubiquitination and proteasomal degradation.
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