ELK Biotechnology SNTA1 rabbit pAb
SNTA1 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 IHC에 사용 가능. 인간 및 생쥐 시료에 반응. 세포막 및 세포골격 단백질 연구에 적합. -20°C에서 1년 보관 가능.
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제품명
SNTA1 rabbit pAb
제품 설명
SNTA1 단백질을 인식하는 토끼 폴리클로날 항체입니다. 인간 및 생쥐 시료에서 사용 가능하며, 웨스턴블롯(WB)과 면역조직화학(IHC)에 적합합니다. 세포막, 세포골격, 신경근 접합부 등에서의 SNTA1 단백질 발현 연구에 활용됩니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from human SNTA1 (AA 289–339) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 6640 |
| Human Swiss-Prot No | Q13424 |
| Species Reactivity | Human; Mouse |
| Cellular Localization | Cell membrane, sarcolemma; peripheral membrane protein; cytoplasmic side; cell junction; cytoplasm, cytoskeleton. In skeletal muscle, localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions. |
Background
Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues.
The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b complex in cardiomyocytes.
This gene is a susceptibility locus for Long-QT syndrome (LQT) and sudden infant death syndrome (SIDS). It also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and affects intracellular calcium ion levels in muscle tissue.
(Provided by RefSeq, Jan 2013)
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