ELK Biotechnology SPAST rabbit pAb

ELK Biotechnology SPAST rabbit pAb

제품 정보

세포 내 위치 (Cellular Localization)

Membrane; Peripheral membrane protein; Endoplasmic reticulum; Midbody; Cytoplasm (cytoskeleton, microtubule organizing center, centrosome, perinuclear region, spindle); Nucleus.
Forms an intramembrane hairpin-like structure in the membrane (PubMed:20200447).
Localization to the centrosome is independent of microtubules (PubMed:15891913).
Localizes to the midbody of dividing cells, requiring CHMP1B (PubMed:18997780).
Enriched in distal axons and branches of postmitotic neurons (PubMed:15269182).
Isoform 1: Endoplasmic reticulum membrane; Peripheral membrane protein; Nucleus membrane; Lipid droplet; Cytoplasm (cytoskeleton, endosome).

Background

This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this family share an ATPase domain and are involved in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis.
The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full-length sequences have not been determined.
Mutations in this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. (RefSeq, Jul 2008)