ELK Biotechnology SPNXA rabbit pAb

제품명

SPNXA rabbit pAb

제품 개요

SPNXA 단백질을 대상으로 제작된 토끼 폴리클로날 항체로, 면역조직화학(IHC) 및 면역형광(IF) 분석에 사용됩니다. 인간, 생쥐, 랫드 시료에서 반응하며, 세포질 및 핵 내 SPNXA 단백질의 위치 연구에 적합합니다.

제품 정보

Background

Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa.
This gene is a member of the SPANX family of cancer/testis-associated genes, located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments.
This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A2, which appears to be a duplication of the A1 locus. The protein encoded by this gene targets the nucleus, where it associates with nuclear vacuoles and the redundant nuclear envelope.
Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatozoa while attempting to further define its role in spermatogenesis. (provided by RefSeq, Jul 2008)