ELK Biotechnology SQSTM1/p62 (phospho-Ser349) rabbit pAb

제품명

SQSTM1/p62 (phospho-Ser349) rabbit pAb

대체 명칭

Sequestosome-1 (EBI3-associated protein of 60 kDa, EBIAP, p60, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p62)

적용 분야 (Applications)

• WB
• ELISA
• IHC

권장 희석 배수 (Recommended Dilutions)

• WB: 1:500–2000
• IHC-p: 1:50–300
• ELISA: 1:2000–20000

면역원 (Immunogen)

Synthesized phospho peptide around human SQSTM1 (Ser349)

보관 및 안정성 (Storage)

• 종: Rabbit
• 보관 조건: -20°C, 1년 안정

항체 특성 (Antibody Properties)

유전자 정보

세포 내 위치 (Cellular Localization)

Cytoplasm, cytosol, late endosome, lysosome, cytoplasmic vesicle (autophagosome), nucleus, endoplasmic reticulum, PML body, myofibril (sarcomere).
In cardiac muscle, localizes to the sarcomeric band (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates.
Detected in Lewy bodies (Parkinson’s disease), neurofibrillary tangles (Alzheimer’s disease), and HTT aggregates (Huntington’s disease).
In liver protein aggregate diseases, found in Mallory bodies (alcoholic/nonalcoholic steatohepatitis), hyaline bodies (hepatocellular carcinoma), and SERPINA1 aggregates.
Enriched in Rosenthal fibers of pilocytic astrocytoma.

배경 (Background)

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the NF-κB signaling pathway. It functions as a scaffolding/adaptor protein with TNF receptor-associated factor 6 to mediate NF-κB activation in response to upstream signals.
Alternatively spliced transcript variants encoding either the same or different isoforms have been identified.
Mutations in this gene are associated with sporadic and familial Paget disease of bone.
[Provided by RefSeq, Mar 2009]