ELK Biotechnology Src (phospho-Ser17) rabbit pAb

Src (phospho-Ser17) Rabbit pAb

제품 개요

Src (phospho-Ser17) rabbit polyclonal antibody는 인산화된 Ser17 부위를 인식하는 항체로, 세포 성장 및 발달 조절 연구에 사용됩니다.

제품 정보

세포 내 위치 (Cellular Localization)

Cell membrane; lipid-anchor; mitochondrion inner membrane; nucleus; cytoplasm (cytoskeleton, perinuclear region); cell junction (focal adhesion).
Localizes to focal adhesion sites following integrin engagement (PubMed:22801373). Localization to focal adhesion sites requires myristoylation and the SH3 domain (PubMed:7525268).
Colocalizes with PDLIM4 at the perinuclear region, but not at focal adhesions (PubMed:19307596).

Background

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]