ELK Biotechnology SRC-3 (phospho-Thr24) rabbit pAb
SRC-3 (phospho-Thr24) rabbit pAb는 인산화된 SRC-3 단백질을 검출하기 위한 고품질 폴리클로날 항체입니다. WB에 적합하며, 인간·쥐·마우스 시료에서 반응합니다. 세포질 및 핵 내 SRC-3의 위치 변화를 연구하는 데 유용합니다.
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SRC-3 (phospho-Thr24) rabbit pAb
제품 개요
SRC-3 (phospho-Thr24) rabbit pAb는 인산화된 SRC-3 단백질을 특이적으로 인식하는 폴리클로날 항체로, 세포 내 신호전달 및 전사활성 조절 연구에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | SRC-3 (phospho-Thr24) rabbit pAb |
| Alternative Names | Nuclear receptor coactivator 3 (NCoA-3), ACTR, AIB-1, CBP-interacting protein (pCIP), Class E basic helix-loop-helix protein 42 (bHLHe42), Receptor-associated coactivator 3 (RAC-3), Steroid receptor coactivator protein 3 (SRC-3), Thyroid hormone receptor activator molecule 1 (TRAM-1) |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human SRC-3 (Thr24) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 160 kD |
| GeneID (Human) | 8202 |
| Human Swiss-Prot No. | Q9Y6Q9 |
| Cellular Localization | Cytoplasm and nucleus. Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, translocates from cytoplasm to nucleus. |
| Species Reactivity | Human, Rat, Mouse |
Background
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. It possesses histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. Initially localized in the cytoplasm, it translocates into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been identified, and a polymorphic repeat region exists in the C-terminus of the protein.
(Information provided by RefSeq, Mar 2010)
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