ELK Biotechnology SSRP1 rabbit pAb
SSRP1 단백질을 인식하는 토끼 폴리클로날 항체로, WB 실험에 적합합니다. 인간, 마우스, 랫트 시료에서 반응하며, 핵 및 염색체에 위치한 SSRP1 단백질 검출에 유용합니다. -20°C에서 1년간 보관 가능합니다.
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SSRP1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | SSRP1 rabbit pAb |
| Applications | WB |
| Recommended Dilutions | WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human SSRP1 (AA range: 209–259) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 6749 |
| Human Swiss-Prot No | Q08945 |
| Species Reactivity | Human, Mouse, Rat |
| Cellular Localization | Nucleus, nucleolus, chromosome. Colocalizes with RNA polymerase II on chromatin and is recruited to actively transcribed loci. |
Background
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms the chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box, which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. (Provided by RefSeq, Jul 2008)
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