ELK Biotechnology TAK1 (phospho-Ser412) rabbit pAb
TAK1 (phospho-Ser412) rabbit pAb는 TGF-β 및 BMP 신호전달 경로 연구에 적합한 항체입니다. WB에 최적화되어 있으며, 인간, 마우스, 랫트 시료에 반응합니다. 세포 내 MAP3K7 단백질의 인산화 상태 분석에 유용합니다. -20°C에서 1년 보관 가능합니다.
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제품명
TAK1 (phospho-Ser412) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25), Transforming growth factor-beta-activated kinase 1 (TGF-beta-activated kinase 1) |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human TAK1 (Ser412) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 70 kDa |
| Gene ID (Human) | 6885 |
| Human Swiss-Prot No. | O43318 |
| Cellular Localization | Cytoplasm, Cell membrane; Peripheral membrane protein; Cytoplasmic side. Although the majority of MAP3K7/TAK1 is found in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2, it is also localized at the cell membrane. |
| Species Reactivity | Human, Mouse, Rat |
Background
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF-β and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1, and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. (provided by RefSeq, Jul 2008)
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