ELK Biotechnology Talin (phospho-Ser425) rabbit pAb
Talin (phospho-Ser425) rabbit polyclonal antibody로, 세포 부착 및 이동 관련 단백질 Talin-1의 인산화 형태를 검출합니다. WB에 적합하며, 인간, 마우스, 랫트에 반응합니다. 세포골격 및 세포막 접착 연구에 유용합니다.
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Talin (phospho-Ser425) Rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Talin (phospho-Ser425) rabbit pAb |
| Alternative Names | Talin-1 |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human Talin (Ser425) |
| Species Reactivity | Human, Mouse, Rat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 269 kDa |
| Gene ID (Human) | 7094 |
| Human Swiss-Prot No. | Q9Y490 |
| Storage | -20°C, 1 year |
| Host | Rabbit |
| Cellular Localization | Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side; Cytoplasm, cytoskeleton; Cell surface; Cell junction, focal adhesion. Colocalizes with LAYN at membrane ruffles. Localized preferentially in focal adhesions rather than fibrillar adhesions (By similarity). |
Background
This gene encodes a cytoskeletal protein concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in actin filament assembly and in the spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins at the cell surface membrane, assisting in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus contains localization elements for cell–extracellular matrix junctions, while the C-terminus has binding sites for beta-1-integrin, actin, and vinculin. [Provided by RefSeq, Feb 2009]
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