ELK Biotechnology TAP2 rabbit pAb

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TAP2 rabbit pAb

제품 정보

Background

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is a member of the MDR/TAP subfamily, which is involved in multidrug resistance. The gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation and forms a heterodimer with ABCB2 to transport peptides from the cytoplasm to the endoplasmic reticulum.
Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.
(provided by RefSeq, Feb 2014)