ELK Biotechnology TAP2 rabbit pAb
TAP2 단백질을 인식하는 토끼 폴리클로날 항체로, WB 분석에 적합합니다. 인간, 마우스, 랫트에 반응하며, 항원은 TAP2의 182-232 아미노산 서열에서 유래한 합성 펩타이드입니다. -20°C에서 1년간 보관 가능하며, 농도는 1 mg/ml입니다.
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제품명
TAP2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB |
| Recommended Dilutions | WB 1:500–2000 |
| Immunogen | Synthesized peptide derived from human TAP2 (AA range: 182–232) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 6891 |
| Human Swiss-Prot No. | Q03519 |
| Cellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein. The transmembrane segments seem to form a pore in the membrane. |
| Species Reactivity | Human, Mouse, Rat |
Background
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is a member of the MDR/TAP subfamily, which is involved in multidrug resistance. The gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation and forms a heterodimer with ABCB2 to transport peptides from the cytoplasm to the endoplasmic reticulum.
Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.
(provided by RefSeq, Feb 2014)
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