ELK Biotechnology Topoisomerase IIα (phospho-Ser1469) rabbit pAb

Topoisomerase IIα (phospho-Ser1469) Rabbit pAb

제품 개요

Topoisomerase IIα (phospho-Ser1469) rabbit polyclonal antibody는 DNA 이중가닥의 절단과 재결합을 통해 DNA의 위상 변화를 조절하는 효소인 Topoisomerase IIα의 인산화된 Ser1469 부위를 특이적으로 인식합니다. 이 항체는 세포 내 염색체 응축, 분리, DNA 복제 및 전사 과정 연구에 유용합니다.

제품 사양

Background

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in genomic instability.