Thermo Fisher Scientific SPACA3 Polyclonal Antibody

Applications

• Western Blot (WB): Tested at 1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 86% | Dog: 86% | Goat: 86% | Horse: 100% | Human: 100% | Mouse: 79% | Pig: 93% | Rabbit: 86% | Rat: 92% | Sheep: 86%

Target Information

SPACA3 (sperm acrosome associated 3), also known as sperm lysozyme-like protein 1, lysozyme-like protein 3, lysozyme-like acrosomal sperm-specific secretory protein ALLP-17, cancer/testis antigen 54 (CT54), LYC3, SPRASA or LYZL3, is a 215 amino acid protein that participates in the fusion and adhesion of sperm and egg plasma membrane during fertilization.
Identified as a novel cancer/testis antigen in hematologic malignancies, SPACA3 can elicit B-cell immune responses in cancer patients and is considered a potential target for immunotherapy.
A member of the glycosyl hydrolase 22 family, expressed in testis, placenta, and epididymis. SPACA3 exists as two alternatively spliced isoforms:

• Isoform 1: Single-pass type II membrane protein of the sperm acrosome
• Isoform 2: Secreted protein

Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It may act as a receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.