Thermo Fisher Scientific Phospho-p53 (Thr387) Polyclonal Antibody
인간 p53 단백질 Thr387 인산화 부위에 특이적인 폴리클로날 항체로, 면역조직화학(IHC) 분석에 적합. Rabbit IgG 기반, 액상 형태로 1 mg/mL 농도. Affinity chromatography로 정제되었으며, -20°C에서 보관. 암 연구 및 p53 신호전달 분석에 유용.
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Thermo Fisher Scientific Phospho-p53 (Thr387) Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:100 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of threonine 387 (F-K-T(p)-E-G) derived from Human p53 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554369 |
Product Specific Information
A suggested positive control for IHC is human breast carcinoma.
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nutrient deprivation. p53 up-regulates stress response genes, including p21waf1, contributing to G1 or G2/M cell cycle arrest.
Structurally, p53 contains:
- N-terminal transactivation domain
- Central DNA-binding domain
- Oligomerisation domain
- C-terminal regulatory domain
Phosphorylation at Ser15 is crucial for activation and stabilization, while Ser392 phosphorylation is associated with tumor formation. p53 plays a key role in preventing proliferation of damaged cells and acts as an anticancer agent. It is also linked to aging, oxidative stress, and cognitive function (LTP deficits). Mutations in the TP53 gene can lead to loss of tumor suppressor activity and are common in various human cancers, including familial Li-Fraumeni syndrome.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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