Thermo Fisher Scientific ICAM-3 Recombinant Rabbit Monoclonal Antibody (003)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to prevent contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select optimal candidates.
Advantages include:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broad immunoreactivity due to the diverse rabbit immune repertoire

This antibody specifically recognizes Human CD50/ICAM-3.

Target Information

CD50 (Intracellular Adhesion Molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes. It serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin.
ICAM-3 mediates adhesion between T cells and antigen-presenting cells, regulates LFA-1 affinity for ICAM-1, and induces T cell activation and proliferation.
It plays an essential role in initiating immune responses and interacts with CD209 (DC-SIGN) on dendritic cells and macrophages, facilitating communication between dendritic cells and granulocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.